PE-22-28 Peptide: The Complete Guide - Uses, Mechanism, Dosing, Safety & Research
PE-22-28 is a synthetic seven-amino-acid peptide derived from spadin, an endogenous inhibitor of the TREK-1 potassium channel in the brain. It was developed as an optimized research compound approximately 333 to 500 times more potent than spadin at the same target, and is studied in preclinical models for antidepressant-like, anxiolytic, and neuroprotective effects through a mechanism entirely distinct from approved drugs. This guide covers what PE-22-28 does, how it works, what the preclinical research shows, dosing context from animal studies, the current safety picture, and its regulatory status.