Endocrine Health

Newest Endocrine Health Information

6 Best Peptides for Pituitary Health

Six peptides show up consistently when people research pituitary health: Sermorelin, CJC-1295, Ipamorelin, Tesamorelin, Gonadorelin, and Kisspeptin-10. They split into two groups by target, four that work through the growth hormone axis and two that support the reproductive axis, and they vary widely in how much human evidence stands behind each one. Tesamorelin carries FDA approval for a specific metabolic indication and has the strongest clinical evidence base of the group. Sermorelin has a history of FDA-recognized diagnostic use and remains available via prescription. CJC-1295 and Ipamorelin were removed from the FDA's permitted compounding list in 2023 and now exist primarily in gray-market channels in the United States. Gonadorelin has decades of clinical use in reproductive medicine. Kisspeptin-10 is still largely a research compound. The entries below are ordered by how prominently each compound appears in research and documented real-world use, not as a ranking of one being better than another for you.

Endocrine Health 12 min read

6 Best Peptides for Adrenal Fatigue

Adrenal fatigue is not a recognized medical diagnosis, but the symptom cluster it describes, persistent exhaustion, disrupted cortisol rhythm, and stress intolerance, points to a real underlying pattern that practitioners and biohackers call HPA axis dysfunction. A growing number of people are turning to peptides to address that pattern, from peptide bioregulators like Glandokort that target adrenal tissue directly to mitochondrial compounds like MOTS-c and NAD+, to stress-modulating options like Selank and DSIP. This guide covers six peptides people actually use or actively discuss for this goal, ordered by how prominently each appears in research and real-world use, not as a recommendation of one over another. The evidence behind each is stated honestly: some have small human studies, some rest on preclinical work or community-reported experience, and the right choice depends on your specific cortisol pattern and situation.

Endocrine Health 10 min read

7 Best Peptides for Adrenal Health

Seven peptides show up consistently when people search for adrenal health support, from Selank and Glandokort to DSIP, Semax, BPC-157, Thymosin Alpha-1, and the CJC-1295 with Ipamorelin combination. What they share is a connection to the HPA axis, the hypothalamic-pituitary-adrenal feedback loop that governs cortisol production and stress response, but each one approaches that connection from a different angle. No peptide is FDA-approved for adrenal fatigue or general HPA support, and the evidence ranges from limited Russian clinical data down to purely user-reported experience. These seven are ordered by how prominently each appears in research and real-world use for this goal, not as a ranking of one being better than another for any individual reader.

Endocrine Health 11 min read

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