Best Supplements to Take With NAD+
NAD+ is not a signaling molecule waiting to bind a receptor. It is a cosubstrate that gets consumed, one molecule at a time, every time a sirtuin (the enzyme family that regulates gene expression and stress resistance) does its job, every time a DNA repair enzyme patches a strand break, and every time a mitochondrion converts fuel into energy. That continuous depletion pressure means supplementing NAD+ without supporting what builds and protects the pool is like filling a leaking tank. The supplements that matter most address three specific pressure points: TMG and folate to handle the methylation demand that increased NAD+ metabolism creates, magnesium because the enzymes that assemble NAD+ from its precursors cannot run without it, and compounds like apigenin that slow CD38 (the enzyme that breaks NAD+ down fastest) to protect the pool you are building. Resveratrol and creatine complete the picture by activating the sirtuins NAD+ fuels and preserving the muscle that NAD+-supported mitochondrial health is meant to protect. The right amounts of each depend on your protocol, your bloodwork, and what else you are taking, which is exactly what the MyPeptidePal app works out.
