Tesamorelin and Ipamorelin: Growth Hormone Secretagogues for Performance and Recovery
Tesamorelin and ipamorelin are two distinct growth hormone secretagogues that act on separate receptor pathways: tesamorelin on the GHRH (growth hormone-releasing hormone) receptor and ipamorelin on the ghrelin receptor. They are frequently combined in wellness and performance protocols to amplify the GH pulse. Tesamorelin is an FDA-approved prescription drug with multiple controlled clinical trials behind it; ipamorelin has minimal human clinical data and no approved indication. This guide covers what each compound does, how they work individually and in combination, what the clinical evidence actually shows, dosing context, safety profiles, regulatory status, and how they compare to alternative approaches.