Pal-GHK Peptide: Research, Benefits, and Clinical Applications
Pal-GHK, also known as Palmitoyl Tripeptide-1, is a synthetic lipopeptide created by attaching a 16-carbon palmitic acid chain to the naturally occurring GHK tripeptide, a glycine-histidine-lysine sequence released from collagen during tissue breakdown. The palmitoyl modification was engineered specifically to solve GHK's main limitation as a topical compound: poor penetration of the stratum corneum, the outermost lipid barrier of the skin. This guide covers what Pal-GHK is, how it works, what controlled research shows about its effects on wrinkle reduction and collagen synthesis, dosing context for topical use, its safety profile, and its current regulatory status.
