Tesofensine: The Complete Guide to This Triple Monoamine Reuptake Inhibitor
Tesofensine is a synthetic small-molecule triple monoamine reuptake inhibitor - not a peptide - that simultaneously increases dopamine, norepinephrine, and serotonin availability in the brain. It is most studied as a weight loss agent, with Phase II clinical trial data showing approximately 9.2% body weight reduction at 0.5 mg daily over 24 weeks, driven primarily by appetite suppression and increased satiety. This guide covers what tesofensine does, how it works mechanistically, what the clinical research shows, dosing ranges studied, its safety profile, and how it compares to approved alternatives.
Tesofensine
24 min read
