7 Best Peptides for Insulin Resistance
Seven peptides show up consistently in the research and real-world conversation about insulin resistance, ranging from FDA-approved GLP-1 receptor agonists with large Phase 3 trial data behind them to investigational mitochondria-derived compounds whose evidence base is still preclinical. Semaglutide and tirzepatide anchor the list as the most thoroughly studied options, while retatrutide, tesamorelin, MOTS-c, 5-Amino-1MQ, and Humanin each fill a distinct role in the landscape. The entries are ordered by how prominently each compound appears in clinical research and documented use, not as a recommendation of one over another, and the evidence for every entry is stated honestly rather than smoothed over.